Denise Wilcox Selected Research

(3b,5b,7a,12a)- 7,12- dihydroxy- 3- (2- ((4- ((11b,17b)- 17- hydroxy- 3- oxo- 17- prop- 1- ynylestra- 4,9- dien- 11- yl) phenyl)(methyl)amino)ethoxy)cholan- 24- oic acid

3/2007	Liver-selective glucocorticoid receptor antagonism decreases glucose production and increases glucose disposal, ameliorating insulin resistance.
7/2005	Hepatic glucocorticoid receptor antagonism is sufficient to reduce elevated hepatic glucose output and improve glucose control in animal models of type 2 diabetes.

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Denise Wilcox Research Topics

Disease

6	Neoplasms (Cancer) 01/2020 - 04/2011
3	Insulin Resistance 03/2007 - 08/2002
3	Type 2 Diabetes Mellitus (MODY) 07/2005 - 08/2002
2	Prostatic Neoplasms (Prostate Cancer) 01/2020 - 01/2017
2	Inflammation (Inflammations) 10/2017 - 12/2004
2	Hematologic Neoplasms (Hematological Malignancy) 01/2017 - 01/2017
2	Pain (Aches) 05/2011 - 12/2004
2	Body Weight (Weight, Body) 03/2007 - 08/2005
1	Disease Progression 01/2017
1	Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse) 01/2017
1	Non-Hodgkin Lymphoma (Lymphosarcoma) 01/2017
1	Multiple Myeloma 01/2017
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2017
1	Hepatocellular Carcinoma (Hepatoma) 11/2013
1	Osteoarthritis 05/2011
1	Chronic Pain 05/2011
1	Arthralgia (Joint Pain) 05/2011
1	Hypoglycemia (Reactive Hypoglycemia) 03/2007
1	Hyperalgesia 12/2004
1	Experimental Arthritis 12/2004
1	Edema (Dropsy) 12/2004
1	Arthritis (Polyarthritis) 12/2004
1	Adrenal Insufficiency (Adrenal Gland Hypofunction) 08/2004
1	Hyperglycemia 06/2003
1	Hyperinsulinism (Hyperinsulinemia) 06/2003

Drug/Important Bio-Agent (IBA)

4	Glucose (Dextrose)FDA LinkGeneric 03/2007 - 08/2004
3	Proteins (Proteins, Gene)FDA Link 01/2020 - 08/2002
3	mivebresibIBA 10/2017 - 01/2017
3	Glucocorticoid Receptors (Glucocorticoid Receptor)IBA 03/2007 - 08/2004
2	Transcription Factors (Transcription Factor)IBA 01/2017 - 06/2003
2	Lipid NanoparticlesIBA 11/2013 - 04/2011
2	Small Interfering RNA (siRNA)IBA 11/2013 - 04/2011
2	Insulin (Novolin)FDA Link 03/2007 - 08/2002
2	(3b,5b,7a,12a)- 7,12- dihydroxy- 3- (2- ((4- ((11b,17b)- 17- hydroxy- 3- oxo- 17- prop- 1- ynylestra- 4,9- dien- 11- yl) phenyl)(methyl)amino)ethoxy)cholan- 24- oic acidIBA 03/2007 - 07/2005
2	Blood Glucose (Blood Sugar)IBA 07/2005 - 08/2002
2	GlucocorticoidsIBA 07/2005 - 08/2004
1	AndrogensIBA 01/2020
1	ABBV-744IBA 01/2020
1	Bromodomain Containing ProteinsIBA 11/2017
1	venetoclaxIBA 01/2017
1	Androgen Receptors (Androgen Receptor)IBA 01/2017
1	Lysine (L-Lysine)FDA Link 01/2017
1	Mitogen-Activated Protein KinasesIBA 05/2011
1	Iodoacetic AcidIBA 05/2011
1	GalactosidasesIBA 04/2011
1	LuciferasesIBA 04/2011
1	CholesterolIBA 08/2005
1	Nonesterified Fatty Acids (NEFA)IBA 08/2005
1	CarrageenanIBA 12/2004
1	2- (3,4- difluorophenyl)- 4- (3- hydroxy- 3- methylbutoxy)- 5- (4- methanesulfonylphenyl)- 2H- pyridazin- 3- oneIBA 12/2004
1	valdecoxib (Bextra)FDA Link 12/2004
1	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 12/2004
1	Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA 12/2004
1	Celecoxib (Celebrex)FDA Link 12/2004
1	Dinoprostone (PGE2)FDA Link 12/2004
1	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 12/2004
1	rofecoxib (Vioxx)FDA Link 12/2004
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 06/2003
1	Cyclic AMP Response Element-Binding Protein (Cyclic AMP-Responsive DNA-Binding Protein)IBA 06/2003
1	Antisense OligonucleotidesIBA 08/2002

Therapy/Procedure

4	Therapeutics 01/2020 - 04/2011
1	Castration 01/2017
1	Intra-Articular Injections 05/2011
1	Catheters 03/2007
1	Oral Administration 12/2004